SARCOPENIC OBESITY – THE DIAGNOSTIC PARADIGM

Authors

  • Natalia Taran “Nicolae Testemiţanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova
  • Iulianna Lupasco “Nicolae Testemiţanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova
  • Inna Vengher “Nicolae Testemiţanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova https://orcid.org/0000-0001-9702-1059
  • Tatiana Ghelimici “Nicolae Testemiţanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova

DOI:

https://doi.org/10.5281/zenodo.10429321

Keywords:

sarcopenic obesity, obesity, sarcopenia

Abstract

Introduction. Sarcopenic obesity is a multifactorial condition characterized by the simultaneous presence of sarcopenia and obesity. Obesity and insulin resistance have been shown to be a risk factor for sarcopenia, and sarcopenic obesity is considered a condition in which skeletal muscle is replaced by fat. Sarcopenic obesity can lead to frailty, disability and increased morbidity and mortality, which is a significant burden on health and social care systems. Studying sarcopenic obesity and effective treatment management are important in relation to the continued growth of the obese population.

Objectives. Analysis of the contemporary literature in view of the etiology, mechanisms of development of sarcopenic obesity, stages, criteria and evaluation methods of sarcopenic obesity.

Material and methods. Contemporary literature analysis focused on the main databases: PubMed, SpringerLink and Scopus (Elsevier) was performed. The keywords used were obesity, sarcopenia, sarcopenic obesity. Inclusion criteria served clinical practice guidelines, scientific articles on current knowledge addressed in the last 10 years: pathophysiology, hormonal changes, management of sarcopenic obesity. Exclusion criteria were articles that did not meet the current requirements and information provided for patients.

The study was realized in the terms of National Programm „Chronic liver and pancreatic diseases: nutritional and surgical aspects” 20.80009.8007.37.

Results. The study includes the etiology and evolutionary mechanisms of sarcopenic obesity, metabolic research, oxidative, inflammatory, hormonal and nutritional stress. The diagnostical approach, criteria and evaluation methods of sarcopenic obesity are presented.

Conclusions. Sarcopenic obesity requires evaluation in persons with increased risk of obesity or who have other clinical comorbidities. The peculiarities of sarcopenic obesity, as well as the methods of treatment and nutritional correction, require further study.

Published

24-12-2023

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