LIPID PROFILE DATA IN CHRONIC VIRAL B INFECTION

Abstract

Introduction. The evolution of chronic HBV infection depends on various factors, conditioned by the pecularities of the virus, as well as by those of the host, among which metabolic risk factors play an important role. This impact is particularly important in inactive HBV disease, in cases with low HBV-DNA, in effective virological suppression after nucleoside(t)ide treatment.

Material and methods. The study group consisted of 76 patients with chronic HBV infection. Group A – 18 patients (23.7%) HBsAg positive; Group B – 58 patients (76.3%) with negative HBsAg /anti HBcor total positive. The control group consisted of 90 practically healthy people. In all participants in the study were evaluated markers of viral infection, lipid profile data (cholesterol, low-density lipids (LDL), high-density lipids (HDL), triglycerides (TG)). Data processing was carried out using the Excel 2016 statistical processing package.

Results. Cholesterol level in the HBV study group was higher versus the (healthy) control group (p<0.01), especially in HBsAg negative/AntiHBcor positive patients (subgroup B), correlating with age in both groups. Women had higher cholesterol level vs men in both groups. The men in the study group (with HBV) were distinguished by higher triglyceride level compared to men in the control group (p<0.05), decrease in HDL-cholesterol (p<0.01) and tendency to increase LDL -cholesterol.

Conclusions. The disturbances of the lipid profile, appreciated in this study, support the hypothesis of the induction of dyslipidemia by HBV infection, including in its inactive HBsAg negative forms. Further in-depth studies are needed to reveal the interrelationship of HBV infection with metabolic risk factors.