REZISTENȚA LA ANTIMICROBIENE A AGENȚILOR PATOGENI SUPRAVEGHEAȚI ÎN REPUBLICA MOLDOVA, 2024

Livia Țapu; Olga Burduniuc; Diana Perde; Natalia Petcoglo; Nadejda Morărescu

doi:10.5281/zenodo.22085932

Authors

Livia Țapu Scientific Laboratory for Surveillance of Antimicrobial Resistance, National Agency for Public Health, Chisinau, Republic of Moldova https://orcid.org/0000-0002-4424-3501
Olga Burduniuc National Agency for Public Health, Chisinau, Republic of Moldova
Diana Perde National Reference Laboratory for Healthcare-Associated Infections and Antimicrobial Resistance, Bacterial Infections and Parasitoses, National Agency for Public Health, Chisinau, Republic of Moldova https://orcid.org/0009-0007-1065-5712
Natalia Petcoglo National Reference Laboratory for Healthcare-Associated Infections and Antimicrobial Resistance, Bacterial Infections and Parasitoses, National Agency for Public Health, Chisinau, Republic of Moldova
Nadejda Morărescu Directorate for Epidemiological Surveillance of Healthcare-Associated Infections and Antimicrobial Resistance, National Agency for Public Health, Chisinau, Republic of Moldova https://orcid.org/0000-0001-7586-9657

DOI:

https://doi.org/10.5281/zenodo.22085932

Keywords:

antimicrobial resistance, epidemiological surveillance, ESBL, carbapenemases, Enterobacterales

Abstract

Objectives. This study characterized antimicrobial-resistance profiles of pathogens under surveillance in the Republic of Moldova in 2024, focusing on invasive, urinary, and enteric isolates reported through the national surveillance system.

Methods. A descriptive analysis was performed using data reported to the National Epidemiological Surveillance System for Antimicrobial Resistance. Isolates from blood and cerebrospinal fluid, urine, and fecal samples were included. Antimicrobial susceptibility was interpreted according to EUCAST criteria, version 14.0, and reporting was aligned with CAESAR and GLASS standards.

Results. A total of 471 invasive isolates were reported, predominantly Klebsiella pneumoniae (28.66%) and Escherichia coli (22.08%). Carbapenem resistance was 70.37% in K. pneumoniae, 90.91% in Acinetobacter spp., and 67.74% in Pseudomonas aeruginosa. Among 3,624 urinary isolates, 76.05% were E. coli and 23.95% were K. pneumoniae. Carbapenem resistance in urinary K. pneumoniae was 31.03%. Extended-spectrum β-lactamase and carbapenemase mechanisms were identified.

Conclusions. The data indicate a substantial burden of multidrug resistance, particularly among Gram-negative bacilli. The findings should be interpreted in relation to surveillance-system coverage, testing quality, and the variable proportion of isolates tested for individual antimicrobials. Strengthened surveillance, laboratory capacity, infection prevention and control, and prudent antimicrobial use are needed.