IMPACT OF GUT MICROBIOTA ON ANKYLOSING SPONDYLITIS EVOLUTION
Keywords:ankylosing spondylitis, intestinal microbiota, ankylosing spondylitis phenotypes
Introduction. Ankylosing spondylitis is the best-studied prototype of spondyloarthritis characterized by sacroiliitis and spondylitis, which can lead to bone ankylosis.
Objective. Predict their gut microbiota in patients with ankylosing spondylitis and identify their specific gut microbiota characteristics for ankylosing spondylitis phenotypes.
Material and methods. In this study, 60 patients were included in the study – 41 patients with ankylosing spondylitis and 19 – in control lot. Patients with ankylosing spondylitis were recruited from the rheumatology and arthrology departments of "Timofei Moșneaga" Republican Clinical Hospital, the clinical base of the Discipline of Rheumatology and Nephrology of "Nicolae Testemitanu" State University of Medicine and Pharmacy, during 2019-2022.
Results. From patients' fecal samples, 52 bacterial species were identified. The predominant genera were defined as comprising more than 1% of all gut bacteria. In the ankylosing spondylitis group, 12 predominant species were detected, of which only 8 species were detected in the control group, including 7 genera detected in both groups. Bacteroides were the species most commonly found in both groups, but with significant reduction in patients with ankylosing spondylitis.
Conclusions. Our study revealed specific changes in the gut microbiome in patients with different phenotypes of ankylosing spondylitis, and the classification model based on gut microbial characteristics could provide a new direction for early clinical diagnosis. What's more, discovering ankylosing spondylitis - associated microbes in the gut microbiome may help us seek more treatments for this severe and disabling pathology.
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