EVALUATION OF THE RESULTS OF LABORATORY EXAMINATION OF WOMEN OF REPRODUCTIVE AGE, WITH ADENOMYOSIS AFTER HAVING EXPERIENCED COVID-19
Keywords:indicators of laboratory examination, women, reproductive age, adenomyosis, COVID-19
The task of the study was to study the clinical assessment of the results of the laboratory examination of women with adenomyosis after suffering from COVID-19.
Research materials and methods. We monitored 30 practically healthy women, 60 women with adenomyosis of the I - II degree of severity, 60 – patients with adenomyosis of the I - IV degree of severity who contracted COVID-19. A clinical and laboratory examination was carried out, which included the study of indicators of clinical and laboratory, biochemical research of biological fluids (blood, urine, vaginal contents), including by the polymerase chain reaction method.
The results. The analysis of the research results showed reliable differences in the indicators studied between the groups of subjects. The presence of blood hypercoagulation processes was found in patients with adenomyosis who suffered a coronavirus infection. Increase in indicators of inflammatory markers: C-Reactive Protein, D-dimer, procalcitonin, lactate dehydrogenase and decrease in ferritin, decrease in the level of vitamin D (total) and magnesium in the blood, total protein, increase in the level of high-density lipoproteins, creatinine, aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase. In the blood of women with adenomyosis who suffered a coronavirus infection, the level of estradiol increased significantly and the content of progesterone, luteinizing and follicle-stimulating hormones decreased. According to the results of the microscopic characteristics of the vaginal biocenosis, the number of observations of the intermediate type, dysbiosis, vaginitis (inflammatory smear type) increased, and a significant increase in the frequency of the herpes simplex virus, cytomegalovirus. Pathogenic flora of aerobic and anaerobic microflora in the vaginal contents was revealed. Histomorphological studies of the tissues of removed organs (uterus, uterine appendages) during surgical treatment confirmed the presence of hypercoagulation, thrombus formation.
Conclusions. In women of reproductive age with adenomyosis, the disease of Сovid-19 is accompanied by a violation of the functional capacity of all organs and systems of the body, the presence of inflammatory processes of the internal genital organs, anemization of the body, hypercoagulation, which represents the risk of blood clot formation. Clinical evaluation of the results of the laboratory examination of women with adenomyosis after suffering from COVID-19 is of practical importance, which consists in the early prevention of possible complications.
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