KIDNEY PATHOLOGY IN SERONEGATIVE SPONDYLOARTHITIS

Abstract

Objectives. To study the renal changes in patients with seronegative spondyloarthritis (ankylosing spondylitis, reactive arthritis and psoriatic arthritis) to highlight the main etiopathogenetic mechanisms of renal injury and its clinical manifestations, which would allow for an early diagnosis, adjust the treatment and to implement measures to prevent complications.

Material and methods. The study included 105 subjects (35 patients with ankylosing spondylitis, 35 patients with reactive arthritis and 35 patients with psoriatic arthritis). The cohort was analyzed multilaterally, according to different distribution groups that met the following criteria: sex, age, place of residence, smoking and alcohol consumption. General physical examination and systemic assessment was performed in all subjects, as well as the results of laboratory and instrumental investigations were analyzed.

Results. According to the observed clinical manifestations, the renal system has been shown to be the most affected among patients with ankylosing spondylitis, a milder affection in patients with psoriatic arthritis, and least affected among patients with reactive arthritis. The degree of kidney damage is directly proportional to the age of the disease: the longer the disease, the more severe the kidney involvement. Risk factors for worsening renal function are high blood pressure (80%), type 2 diabetes mellitus (60%), dyslipidemia (50%) and hyperuricemia (20%).

Conclusions. An early diagnosis can allow us an early management, which will allow us to preserve patients’ kidney function.