PARTICULARS OF HISTOLOGICAL EXAMINATION IN THYROID CARCINOMA ASSOCIATED WITH AUTOIMMUNE THYROIDITIS

Authors

  • Ina Sclifos State University of Medicine and Pharmacy “Nicolae Testemiţanu”, Chișinău, Republic of Moldova

DOI:

https://doi.org/10.5281/zenodo.5765490

Keywords:

thyroid carcinoma, autoimmune thyroiditis, histological examination

Abstract

Objectives. The aim of the study was to analyse the histopathological features for optimizing the diagnostic-curative management of patients with thyroid cancer associated with autoimmune thyroiditis.

Material and methods. This work was performed within the Oncological Institute of the Republic of Moldova. The study was descriptive, integral and analytical of the observational cohort. The research was conducted during the 2017-2020 years, with the approval of the Research Ethics Committee of the State University of Medicine and Pharmacy "Nicolae Testemițanu" of the Republic of Moldova, minutes no. 76 from 14.11.2016. Patients included in the research met the criteria for inclusion in the study (patient acceptance with informed consent, age, patients with thyroid cancer developed on a healthy background and on the background of autoimmune thyroiditis).

Results. We analyzed 234 cases hospitalized in the scientific laboratory tumors head and neck region, during 2017-2020 years.

Conclusions. In the Republic of Moldova, thyroid carcinoma is manifested histopathologically through 4 basic forms: papillary carcinoma (87%), follicular carcinoma (4%), medullary carcinoma (8%), undifferentiated (1%). Papillary and medullary thyroid carcinoma in our research are found in a higher percentage than in other studies, which we can not say about follicular carcinoma, which has fewer cases. Data on undifferentiated carcinoma corresponded to those in the literature. In the case of thyroid carcinomas associated with autoimmune thyroiditis, all these types were present except for undifferentiated carcinoma. Analyzing the histological examinations, we determined the presence of a different number of foci in the thyroid gland at the same time, they being unifocal, bifocal and multifocal, but the unifocal ones predominate. The factors that influenced these results are not known.

Objectives. The aim of the study was to analyse the histopathological features for optimizing the diagnostic-curative management of patients with thyroid cancer associated with autoimmune thyroiditis.

Material and methods. This work was performed within the Oncological Institute of the Republic of Moldova. The study was descriptive, integral and analytical of the observational cohort. The research was conducted during the 2017-2020 years, with the approval of the Research Ethics Committee of the State University of Medicine and Pharmacy "Nicolae Testemițanu" of the Republic of Moldova, minutes no. 76 from 14.11.2016. Patients included in the research met the criteria for inclusion in the study (patient acceptance with informed consent, age, patients with thyroid cancer developed on a healthy background and on the background of autoimmune thyroiditis).

Results. We analyzed 234 cases hospitalized in the scientific laboratory tumors head and neck region, during 2017-2020 years.

Conclusions. In the Republic of Moldova, thyroid carcinoma is manifested histopathologically through 4 basic forms: papillary carcinoma (87%), follicular carcinoma (4%), medullary carcinoma (8%), undifferentiated (1%). Papillary and medullary thyroid carcinoma in our research are found in a higher percentage than in other studies, which we can not say about follicular carcinoma, which has fewer cases. Data on undifferentiated carcinoma corresponded to those in the literature. In the case of thyroid carcinomas associated with autoimmune thyroiditis, all these types were present except for undifferentiated carcinoma. Analyzing the histological examinations, we determined the presence of a different number of foci in the thyroid gland at the same time, they being unifocal, bifocal and multifocal, but the unifocal ones predominate. The factors that influenced these results are not known.

Published

07-12-2021

Issue

Section

ORIGINAL RESEARCHES