CAN WE SPEAK ABOUT RECOMPENSATION IN VIRAL LIVER CIRRHOSIS?

Authors

  • Ecaterina Cebanu Department of Internal Medicine, Gastroenterology Discipline, “Nicolae Testemiţanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova https://orcid.org/0000-0003-0368-1692

DOI:

https://doi.org/10.5281/zenodo.11106874

Keywords:

recompensation of cirrhosis, reversibility of fibrosis, fibrinogenesis

Abstract

Objectives. The purpose of the present paper is to study the mechanisms of development of fibrinogenesis and the current possibilities of reversibility of liver cirrhosis determined by viral causes.

Materials and methods. A structured search was performed in the PubMed electronic database, taking into account relevant articles, published in the last 13 years. The English terms used in search were: ”recompensation of chirrosis”, “reversal”, “fibrinogenesis”.

Results. Viral hepatopathies with persistent lesions over time can lead to the development of liver fibrosis which can later culminate in cirrhosis. The pathophysiological mechanisms of these processes possess common signaling pathways by stimulating hepatic stellate cells in their active forms, with the accumulation of collagen and other components of the extracellular matrix. As the final process of accumulation occurs, the liver structures are destroyed with a decrease in liver function. The avalanche of information provides evidence of the reversibility of liver fibrosis. Currently, the reward concept of liver cirrhosis implies a clear interest in the mechanisms underlying liver fibrosis and its reversal, which can be used as potential treatment targets to inhibit fibrosis, but research data continue to be limited. Controversy still exists regarding the timing of evaluation, evaluation indicators, influencing factors, and long-term prognosis of reward.

Conclusions. Reversal of viral liver cirrhosis is a reality. The multitude of data indicates that liver fibrosis is a dynamic process with a capacity for recovery and remodeling.

Published

03-05-2024

Issue

Section

REVIEW ARTICLES